特瑞普利单抗联合西妥昔单抗二线治疗复发或转移性头颈部鳞状细胞癌耐受良好疗效初显

2022-06-13

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2022年美国临床肿瘤学会(American Society of Clinical Oncology,ASCO)年会于6月7日官网以壁报( #14)形式公布了由同济大学附属东方医院郭晔教授牵头的一项旨在评估特瑞普利单抗联合西妥昔单抗治疗铂类难治性复发或转移性头颈部鳞状细胞癌(R/M-HNSCC)患者研究的安全性和疗效初步结果。本次报告的Ib期初步结果显示:中位随访6.9个月后,特瑞普利单抗联合西妥昔单抗治疗R/M-HNSCC耐受性良好,在12例可评估的患者中,6例患者获得部分缓解(PR),6例患者疾病稳定(SD),客观缓解率(ORR)为50%,疾病控制率(DCR)为100%。

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